103829-46-5
103829-46-5
Chemical Structure
Pyrazine diazohydroxide sodium
Synonym(s): NSC-361456 sodium
- CAS No.: 103829-46-5
- Formula:C4H4N4NaO
- Molecular Weight:147.09
IUPAC Name: N-(pyrazin-2-yl)nitrous amide, sodium salt
InChIKey: XTOCSIBVQAGWAN-UHFFFAOYSA-N
SMILES: O=NNC1=NC=CN=C1.[Na]
Biological Activity: Pyrazine diazohydroxide (NSC 361456) sodium is an anti-tumor agent that forms DNA adducts via the reactive pyrazine diazonium ion. Pyrazine diazohydroxide sodium can be used for the study of renal cancer, colorectal cancer, melanoma and leukemia[1][2].
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Pyrazine diazohydroxide sodium | Pyrazine diazohydroxide (NSC 361456) sodium is an anti-tumor agent that forms DNA adducts via the reactive pyrazine diazonium ion. Pyrazine diazohydroxide sodium can be used for the study of renal cancer, colorectal cancer, melanoma and leukemia. | |||||||||||||||||||||
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References
- [1]. Harrison SD Jr, et al. Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo. Cancer Chemother Pharmacol. 1990;25(6):425-9. [Content Brief]
- [2]. Vogelzang NJ, et al. Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer. Clin Cancer Res. 1998 Apr;4(4):929-34. [Content Brief]
Keywords
