2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Pyrazine diazohydroxide sodium

Pyrazine diazohydroxide sodium  (Synonyms: NSC-361456 sodium)

Cat. No.: HY-19045
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Pyrazine diazohydroxide (NSC 361456) sodium is an anti-tumor agent that forms DNA adducts via the reactive pyrazine diazonium ion. Pyrazine diazohydroxide sodium can be used for the study of renal cancer, colorectal cancer, melanoma and leukemia.

For research use only. We do not sell to patients.

Pyrazine diazohydroxide sodium

Pyrazine diazohydroxide sodium Chemical Structure

CAS No. : 103829-46-5

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Pyrazine diazohydroxide sodium Related Antibodies

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Description

Pyrazine diazohydroxide (NSC 361456) sodium is an anti-tumor agent that forms DNA adducts via the reactive pyrazine diazonium ion. Pyrazine diazohydroxide sodium can be used for the study of renal cancer, colorectal cancer, melanoma and leukemia[1][2].

In Vivo

Pyrazine diazohydroxide (sodium) (44.5-150 mg/kg, i.p., once each on Day 12, 16, and 20) shows significantly higher tumor cell killing effect on lung metastases in LOX melanoma ascites cells xenograft mice compared to primary tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (NCr-nu) were subcutaneously (s.c.) inoculated with 1 × 10⁶ LOX cells, resulting in spontaneous lung metastasis[1].
Dosage: 44.5 mg/kg, 66.7 mg/kg, 150 mg/kg
Administration: I.p., once each on Day 12, 16, and 20
Result: Primary tumor: approximately 2.5 log10 Lung metastases: approximately 4.6 log10
Molecular Weight

147.09

Formula

C4H4N4NaO
CAS No.
SMILES

O=NNC1=NC=CN=C1.[Na]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Pyrazine diazohydroxide sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyrazine diazohydroxide103829-46-5NSC-361456NSC361456NSC 361456DNA/RNA SynthesisPZDHRenal cell carcinomaInhibitorinhibitorinhibit

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