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Cat. No.: HY-19045

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Pyrazine diazohydroxide sodium

Name: Pyrazine diazohydroxide sodium
Brand: MedChemExpress
SKU: HY-19045
Availability: PreOrder

(Synonyms: NSC-361456 sodium)

Pyrazine diazohydroxide (NSC 361456) sodium is an anti-tumor agent that forms DNA adducts via the reactive pyrazine diazonium ion. Pyrazine diazohydroxide sodium can be used for the study of renal cancer, colorectal cancer, melanoma and leukemia.

For research use only. We do not sell to patients.

CAS No.: 103829-46-5
Formula: C₄H₄N₄NaO
Molecular Weight:147.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Pyrazine diazohydroxide sodium Chemical Structure

CAS No.: 103829-46-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vivo

Pyrazine diazohydroxide (sodium) (44.5-150 mg/kg, i.p., once each on Day 12, 16, and 20) shows significantly higher tumor cell killing effect on lung metastases in LOX melanoma ascites cells xenograft mice compared to primary tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female nude mice (NCr-nu) were subcutaneously (s.c.) inoculated with 1 × 10⁶ LOX cells, resulting in spontaneous lung metastasis^[1].
Dosage:

44.5 mg/kg, 66.7 mg/kg, 150 mg/kg
Administration:

I.p., once each on Day 12, 16, and 20
Result:

Primary tumor: approximately 2.5 log₁₀ Lung metastases: approximately 4.6 log₁₀

Chemical Information

CAS No. 103829-46-5
Molecular Weight 147.09
Formula C₄H₄N₄NaO
SMILES

O=NNC1=NC=CN=C1.[Na]
Synonyms

NSC-361456 sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Harrison SD Jr, et al. Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo. Cancer Chemother Pharmacol. 1990;25(6):425-9. [Content Brief]

[2]. Vogelzang NJ, et al. Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer. Clin Cancer Res. 1998 Apr;4(4):929-34. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Pyrazine diazohydroxide sodium

All DNA/RNA Synthesis Isoforms