106-87-6
Chemical Structure
4-Vinylcyclohexene dioxide
Synonym(s): Vinylcyclohexene diepoxide
- CAS No.: 106-87-6
- Formula:C8H12O2
- Molecular Weight:140.18
IUPAC Name: 3-(oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane
InChIKey: OECTYKWYRCHAKR-UHFFFAOYSA-N
SMILES: C1(C2CCC3OC3C2)CO1
Biological Activity: 4-Vinylcyclohexene dioxide (4-Vinylcyclohexene diepoxide) is an orally active metabolite of 4-vinylcyclohexene. 4-Vinylcyclohexene dioxide induces Apoptosis, increases intracellular ROS, and activates the PI3K/Akt/mTOR pathway. 4-Vinylcyclohexene dioxide selectively damages small ovarian follicles, inhibits granulosa cell function, and disrupts the male reproductive system. 4-Vinylcyclohexene dioxide can be used in the study of premature ovarian insufficiency, reproductive toxicity, and related fertility disorders[1][2][3][4][5][6].
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4-Vinylcyclohexene dioxide | 98.57% | 4-Vinylcyclohexene dioxide (4-Vinylcyclohexene diepoxide) is an orally active metabolite of 4-vinylcyclohexene. 4-Vinylcyclohexene dioxide induces Apoptosis, increases intracellular ROS, and activates the PI3K/Akt/mTOR pathway. 4-Vinylcyclohexene dioxide selectively damages small ovarian follicles, inhibits granulosa cell function, and disrupts the male reproductive system. 4-Vinylcyclohexene dioxide can be used in the study of premature ovarian insufficiency, reproductive toxicity, and related fertility disorders. | ||||||||||||||||||||
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4-Vinylcyclohexene dioxide (Standard) | ≥98% | 4-Vinylcyclohexene dioxide (Standard) is the analytical standard of 4-Vinylcyclohexene dioxide (HY-106591A). This product is intended for research and analytical applications. 4-Vinylcyclohexene dioxide (4-Vinylcyclohexene diepoxide) is an orally active metabolite of 4-vinylcyclohexene. 4-Vinylcyclohexene dioxide induces Apoptosis, increases intracellular ROS, and activates the PI3K/Akt/mTOR pathway. 4-Vinylcyclohexene dioxide selectively damages small ovarian follicles, inhibits granulosa cell function, and disrupts the male reproductive system. 4-Vinylcyclohexene dioxide can be used in the study of premature ovarian insufficiency, reproductive toxicity, and related fertility disorders. | ||||||||||||||||||||
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- [1]. Hu X, et al. Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades. Biol Reprod. 2001 Jul;65(1):87-93. [Content Brief]
- [2]. Song W, et al. 4-vinylcyclohexene diepoxide induces apoptosis by excessive reactive oxygen species and DNA damage in human ovarian granulosa cells. Toxicol In Vitro. 2023 Sep;91:105613. [Content Brief]
- [3]. Cao LB, et al. Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development. Front Cell Dev Biol. 2020 Jul 31;8:587. [Content Brief]
- [4]. Miao Y, et al. Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells. In Vitro Cell Dev Biol Anim. 2022 Mar;58(3):220-231. [Content Brief]
- [5]. Kao SW, et al. Early effects of ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats and mice. Reprod Toxicol. 1999 Jan-Feb;13(1):67-75. [Content Brief]
- [6]. Adedara IA, et al. 4-Vinylcyclohexene diepoxide disrupts sperm characteristics, endocrine balance and redox status in testes and epididymis of rats. Redox Rep. 2017 Nov;22(6):388-398. [Content Brief]
