1079821-35-4
Chemical Structure
GPR120 Agonist 5
- CAS No.: 1079821-35-4
- Formula:C23H24N2O3
- Molecular Weight:376.45
IUPAC Name: 4-(4-(2-(phenyl(pyridin-2-yl)amino)ethoxy)phenyl)butanoic acid
InChIKey: WQXHZCYCKCQFQP-UHFFFAOYSA-N
SMILES: O=C(CCCC1=CC=C(C=C1)OCCN(C2=CC=CC=C2)C3=NC=CC=C3)O
Biological Activity: GPR120 Agonist 5 (compound 12) is an agonist targeting GPR120 (EC50=1.2 μM). GPR120 Agonist 5 promotes the release of glucagon-like 1 (GLP-1) by binding to the GPR120 receptor, which in turn binds to its receptors on pancreatic beta cells, increasing insulin secretion and thereby lowering blood sugar levels. GPR120 Agonist 5 also helps reduce chronic low-grade inflammation, which plays an important role in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. GPR120 Agonist 5 can be used to investigate the mechanism of action of GPR120 in metabolic and inflammatory diseases[1][2].
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GPR120 Agonist 5 | GPR120 Agonist 5 (compound 12) is an agonist targeting GPR120 (EC50=1.2 μM). GPR120 Agonist 5 promotes the release of glucagon-like 1 (GLP-1) by binding to the GPR120 receptor, which in turn binds to its receptors on pancreatic beta cells, increasing insulin secretion and thereby lowering blood sugar levels. GPR120 Agonist 5 also helps reduce chronic low-grade inflammation, which plays an important role in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. GPR120 Agonist 5 can be used to investigate the mechanism of action of GPR120 in metabolic and inflammatory diseases. | |||||||||||||||||||||
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- [1]. Suzuki T, et al. Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists[J]. Journal of medicinal chemistry, 2008, 51(23): 7640-7644. [Content Brief]
- [2]. Shimpukade B, et al. Discovery of a potent and selective GPR120 agonist[J]. Journal of medicinal chemistry, 2012, 55(9): 4511-4515. [Content Brief]
Keywords
