GPR120 Agonist 5
GPR120 Agonist 5 (compound 12) is an agonist targeting GPR120 (EC50=1.2 μM). GPR120 Agonist 5 promotes the release of glucagon-like 1 (GLP-1) by binding to the GPR120 receptor, which in turn binds to its receptors on pancreatic beta cells, increasing insulin secretion and thereby lowering blood sugar levels. GPR120 Agonist 5 also helps reduce chronic low-grade inflammation, which plays an important role in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. GPR120 Agonist 5 can be used to investigate the mechanism of action of GPR120 in metabolic and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 1079821-35-4
- Formula: C23H24N2O3
- Molecular Weight:376.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
1.2 μM
Compound: 12
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Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
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[PMID: 19007110] |
| HEK293 | EC50 |
19 μM
Compound: 12
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Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
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[PMID: 19007110] |
Chemical Information
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CAS No. 1079821-35-4
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Molecular Weight 376.45
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Formula C23H24N2O3
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SMILES
O=C(CCCC1=CC=C(C=C1)OCCN(C2=CC=CC=C2)C3=NC=CC=C3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Suzuki T, et al. Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists[J]. Journal of medicinal chemistry, 2008, 51(23): 7640-7644. [Content Brief]
[2]. Shimpukade B, et al. Discovery of a potent and selective GPR120 agonist[J]. Journal of medicinal chemistry, 2012, 55(9): 4511-4515. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPR120 Agonist 5 Related Classifications
HY-109692 Related Classifications
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