111321-67-6
![[Pt(DACH)(OH)2(ox)] Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-w778423.gif "[Pt(DACH)(OH)2(ox)] Chemical Structure")
Chemical Structure
[Pt(DACH)(OH)2(ox)]
Synonym(s): Dihydroxy Oxaliplatin-Pt(IV)
- CAS No.: 111321-67-6
- Formula:C8H16N2O6Pt
- Molecular Weight:431.31
InChIKey: CRUOOYJLGQUXMM-NDSUJOINSA-J
SMILES: [OH-][Pt+4]12([NH2][C@@]3([H])[C@](CCCC3)([H])[NH2]1)([O-]C(C([O-]2)=O)=O)[OH-]
Biological Activity: [Pt(DACH)(OH)2(ox)] is a Pt(IV) derivative of Oxaliplatin (HY-17371) with two axial hydroxido ligands, used as a precursor for synthesizing Pt(IV)-HDAC inhibitor prodrugs. [Pt(DACH)(OH)2(ox)] exerts cytotoxic activity against human cancer cells and accumulates in cancer cells for nuclear internalization and nuclear DNA platination. [Pt(DACH)(OH)2(ox)] can be used for the research of lung carcinoma, breast carcinoma, pancreatic carcinoma, colon carcinoma[1].
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[Pt(DACH)(OH)2(ox)] | 98% | [Pt(DACH)(OH)2(ox)] is a Pt(IV) derivative of Oxaliplatin (HY-17371) with two axial hydroxido ligands, used as a precursor for synthesizing Pt(IV)-HDAC inhibitor prodrugs. [Pt(DACH)(OH)2(ox)] exerts cytotoxic activity against human cancer cells and accumulates in cancer cells for nuclear internalization and nuclear DNA platination. [Pt(DACH)(OH)2(ox)] can be used for the research of lung carcinoma, breast carcinoma, pancreatic carcinoma, colon carcinoma. | ||||||||||||||||||||
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Keywords
