[Pt(DACH)(OH)2(ox)]
Based on 1 Customer Validation
[Pt(DACH)(OH)2(ox)] is a Pt(IV) derivative of Oxaliplatin (HY-17371) with two axial hydroxido ligands, used as a precursor for synthesizing Pt(IV)-HDAC inhibitor prodrugs. [Pt(DACH)(OH)2(ox)] exerts cytotoxic activity against human cancer cells and accumulates in cancer cells for nuclear internalization and nuclear DNA platination. [Pt(DACH)(OH)2(ox)] can be used for the research of lung carcinoma, breast carcinoma, pancreatic carcinoma, colon carcinoma.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 111321-67-6
- Formula: C8H16N2O6Pt
- Molecular Weight:431.31
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
![[Pt(DACH)(OH)2(ox)] Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w778423.gif "Click to View [Pt(DACH)(OH)2(ox)] Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
[Pt(DACH)(OH)2(ox)] (Dihydroxy Oxaliplatin-Pt(IV)) (72 h) exhibits cytotoxic activity against MCF-7, A549, HCT-15, PC3, A498, BxPC3, and A375 cancer cell lines with an average IC50 of 13.2 μM[1].
[Pt(DACH)(OH)2(ox)] (24 h) does not inhibit HDAC activity in MCF-7 cells or isolated MCF-7 nuclei[1].
[Pt(DACH)(OH)2(ox)] (19.88 μM; 12-24 h) induces minimal nuclear DNA fragmentation in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7
-
Concentration:19.88 μM
-
Incubation Time:12 h; 24 h
-
Result:Induced lower levels of nucleosome formation than bis-valproate and bis-phenylbutyrate cisplatin Pt(IV) derivatives (I and VI) and cisplatin.
Showed nucleosome formation levels only slightly above untreated control cells after 24 hours.
Chemical Information
-
CAS No. 111321-67-6
-
Appearance Solid
-
Molecular Weight 431.31
-
Formula C8H16N2O6Pt
-
Color White to off-white
-
SMILES
[OH-][Pt+4]12([NH2][C@@]3([H])[C@](CCCC3)([H])[NH2]1)([O-]C(C([O-]2)=O)=O)[OH-]
-
Synonyms
Dihydroxy Oxaliplatin-Pt(IV)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[Pt(DACH)(OH)2(ox)] Related Classifications
HY-W778423 Related Classifications
Powered by Bioz