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  4. [Pt(DACH)(OH)2(ox)]

[Pt(DACH)(OH)2(ox)]  (Synonyms: Dihydroxy Oxaliplatin-Pt(IV))

Cat. No.: HY-W778423 Purity: 98%
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[Pt(DACH)(OH)2(ox)] is a Pt(IV) derivative of Oxaliplatin (HY-17371) with two axial hydroxido ligands, used as a precursor for synthesizing Pt(IV)-HDAC inhibitor prodrugs. [Pt(DACH)(OH)2(ox)] exerts cytotoxic activity against human cancer cells and accumulates in cancer cells for nuclear internalization and nuclear DNA platination. [Pt(DACH)(OH)2(ox)] can be used for the research of lung carcinoma, breast carcinoma, pancreatic carcinoma, colon carcinoma.

For research use only. We do not sell to patients.

[Pt(DACH)(OH)2(ox)]

[Pt(DACH)(OH)2(ox)] Chemical Structure

CAS No. : 111321-67-6

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[Pt(DACH)(OH)2(ox)] Related Antibodies

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Description

[Pt(DACH)(OH)2(ox)] is a Pt(IV) derivative of Oxaliplatin (HY-17371) with two axial hydroxido ligands, used as a precursor for synthesizing Pt(IV)-HDAC inhibitor prodrugs. [Pt(DACH)(OH)2(ox)] exerts cytotoxic activity against human cancer cells and accumulates in cancer cells for nuclear internalization and nuclear DNA platination. [Pt(DACH)(OH)2(ox)] can be used for the research of lung carcinoma, breast carcinoma, pancreatic carcinoma, colon carcinoma[1].

In Vitro

[Pt(DACH)(OH)2(ox)] (Dihydroxy Oxaliplatin-Pt(IV)) (72 h) exhibits cytotoxic activity against MCF-7, A549, HCT-15, PC3, A498, BxPC3, and A375 cancer cell lines with an average IC50 of 13.2 μM[1].
[Pt(DACH)(OH)2(ox)] (24 h) does not inhibit HDAC activity in MCF-7 cells or isolated MCF-7 nuclei[1].
[Pt(DACH)(OH)2(ox)] (19.88 μM; 12-24 h) induces minimal nuclear DNA fragmentation in MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Pt(DACH)(OH)2(ox)] Related Antibodies

Apoptosis Analysis[1]

Cell Line: MCF-7
Concentration: 19.88 μM
Incubation Time: 12 h; 24 h
Result: Induced lower levels of nucleosome formation than bis-valproate and bis-phenylbutyrate cisplatin Pt(IV) derivatives (I and VI) and cisplatin.
Showed nucleosome formation levels only slightly above untreated control cells after 24 hours.
Molecular Weight

431.31

Formula

C8H16N2O6Pt
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[OH-][Pt+4]12([NH2][C@@]3([H])[C@](CCCC3)([H])[NH2]1)([O-]C(C([O-]2)=O)=O)[OH-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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[Pt(DACH)(OH)2(ox)] Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Pt(DACH)(OH)2(ox)]111321-67-6Dihydroxy Oxaliplatin-Pt(IV)Drug IntermediateDrug Iintermediatehuman cancer cellsA549MCF-7pancreatic carcinomamelanomacolon carcinomalung carcinomaprostate carcinomabreast carcinomakidney carcinomaInhibitorinhibitorinhibit

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