1126623-89-9
1126623-89-9
Chemical Structure
Axitinib-d3
Synonym(s): AG-013736-d3
- CAS No.: 1126623-89-9
- Formula:C22H15D3N4OS
- Molecular Weight:389.49
IUPAC Name: (E)-N-(methyl-d3)-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
InChIKey: RITAVMQDGBJQJZ-VOTVRPQJSA-N
SMILES: O=C(NC([2H])([2H])[2H])C1=CC=CC=C1SC2=CC3=C(C=C2)C(/C=C/C4=NC=CC=C4)=NN3
Biological Activity: Axitinib-d3 (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Axitinib-d3 | 98.07% | Axitinib-d3 (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. | ||||||||||||||||||||
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Axitinib (Standard) | 99.58% | Axitinib (Standard) is the analytical standard of Axitinib. This product is intended for research and analytical applications. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. | ||||||||||||||||||||
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Axitinib-13C,d3 | 97.80% | Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50 values of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. | ||||||||||||||||||||
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Axitinib | 99.84% | Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-10920Axitinib analogue 1 -
Similarity Score 0.81
HY-137110Axitinib sulfoxide -
Similarity Score 0.63
HY-163533CPD-002 -
Similarity Score 0.61
HY-128589CHMFL-KIT-033 -
Similarity Score 0.58
HY-150561Trk-IN-20 -
Similarity Score 0.55
HY-Z4731Axitinib impurity 7 -
Similarity Score 0.54
HY-119370CHMFL-ABL-121 -
Similarity Score 0.52
HY-115589YLT-11 -
Explore the MedChemAI to find more analogs
