1. Protein Tyrosine Kinase/RTK
  2. VEGFR PDGFR
  3. Axitinib-13C,d3

Axitinib-13C,d3  (Synonyms: AG-013736-13C,d3)

Cat. No.: HY-10065S Purity: 97.80%
COA Handling Instructions

Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

For research use only. We do not sell to patients.

Axitinib-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Axitinib-13C,d3 Chemical Structure

CAS No. : 1261432-00-1

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Based on 1 publication(s) in Google Scholar

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Description

Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

390.48

Formula

C2113CH15D3N4OS

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[2H][13C]([2H])([2H])NC(C(C=CC=C1)=C1SC2=CC=C3C(/C=C/C4=CC=CC=N4)=NNC3=C2)=O

Shipping

Shipping with dry ice.

Storage

-80°C

Purity & Documentation
References
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Axitinib-13C,d3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Axitinib-13C,d3
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