1132641-20-3
1132641-20-3
Chemical Structure
Rosiglitazone-d4-1
Synonym(s): BRL 49653-d4-1
- CAS No.: 1132641-20-3
- Formula:C18H15D4N3O3S
- Molecular Weight:361.45
InChIKey: YASAKCUCGLMORW-KDWZCNHSSA-N
SMILES: O=C(N1)SC(CC2=C([2H])C([2H])=C(OCCN(C)C3=NC=CC=C3)C([2H])=C2[2H])C1=O
Biological Activity: Rosiglitazone-d4-1 (BRL 49653-d4-1) is deuterium-labeled Rosiglitazone (HY-17386)[1].
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Rosiglitazone-d4-1 | Rosiglitazone-d4-1 (BRL 49653-d4-1) is deuterium-labeled Rosiglitazone (HY-17386). | |||||||||||||||||||||
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Rosiglitazone (Standard) | 99.59% | Rosiglitazone (Standard) is the analytical standard of Rosiglitazone. This product is intended for research and analytical applications. Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer. | ||||||||||||||||||||
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Rosiglitazone-d4 | Rosiglitazone-d4 is deuterated labeled Rosiglitazone (HY-17386). Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer. | |||||||||||||||||||||
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Rosiglitazone-d3 | Rosiglitazone-d3 is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC50=~30 μM) and an inhibitor of TRPM3. | |||||||||||||||||||||
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Rosiglitazone | 99.94% | Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM), with blood-brain barrier permeability. Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer. | ||||||||||||||||||||
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References
