113303-81-4
Chemical Structure
CGP 4832
- CAS No.: 113303-81-4
- Formula:C49H65N3O15
- Molecular Weight:936.05
InChIKey: FRCBXOTYSDSELT-DUULCSDKSA-N
SMILES: CO[C@H]1/C=C/O[C@@]2(C)OC3=C(C4=C(C(O)=C3C)C(C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(CC(OCC5CCCN(C)C5)=O)=O)[C@@H]1C)=O)=C(N6CCOCC6)C4=O)=O)C2=O
Biological Activity: CGP 4832 is a Rifamycin S (HY-125365) derivative and Antibacterial agent. CGP 4832 inhibits DNA-dependent transcription through DNA-dependent RNA polymerase. CGP 4832 exhibits activity against Gram-positive bacteria comparable to Rifampicin (HY-B0272), but is more potent against certain Gram-negative bacterial species, such as Escherichia coli ETH 2018 (MIC 0.01 µg/mL) and Salmonella AX 5 (MIC 0.5 µg/mL). CGP 4832 can be used for research on Gram-negative bacterial infections[1][2].
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CGP 4832 | CGP 4832 is a Rifamycin S (HY-125365) derivative and Antibacterial agent. CGP 4832 inhibits DNA-dependent transcription through DNA-dependent RNA polymerase. CGP 4832 exhibits activity against Gram-positive bacteria comparable to Rifampicin (HY-B0272), but is more potent against certain Gram-negative bacterial species, such as Escherichia coli ETH 2018 (MIC 0.01 µg/mL) and Salmonella AX 5 (MIC 0.5 µg/mL). CGP 4832 can be used for research on Gram-negative bacterial infections. | |||||||||||||||||||||
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References
- [1]. Lu P, et al. Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates. PloS one. 2023;18(6):e0287102. [Content Brief]
- [2]. Wehrli W, et al. CGP 4832, a new semisynthetic rifamycin derivative highly active against some gram-negative bacteria. The Journal of antibiotics. 1987 Dec;40(12):1733-9. [Content Brief]
