Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates

  • PLoS One. 2023 Jun 13;18(6):e0287102. doi: 10.1371/journal.pone.0287102.
Peggy Lu  1 ,  Francesco Alletto  2 ,  Bosul Lee  1 ,  Elizabeth Burk  1 ,  Jasmine Martinez  1 ,  Fabio Prati  2 ,  Emilia Caselli  2 ,  Brad Spellberg  3 ,  Brian Luna  1
Affiliations
  • 1. Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, United States of America.
  • 2. Department of Life Science, University of Modena and Reggio Emilia, Modena, Italy.
  • 3. Los Angeles General Medical Center, Los Angeles, California, United States of America.
PMID: 37310985 DOI: 10.1371/journal.pone.0287102
Abstract

Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also display hyper-activity when tested in iron-limited media against A. baumannii, K. pneumoniae, and E. coli. MICs were determined against representative clinical isolates using the iron-limited media RPMI-1640. Only rifabutin was hyperactive against A. baumannii.

Products