1217705-21-9
Chemical Structure
Selegiline-d5 hydrochloride
Synonym(s): Deprenyl-d5 hydrochloride; (-)-Selegiline-d5 hydrochloride; (-)-Deprenyl-d5 hydrochloride
- CAS No.: 1217705-21-9
- Formula:C13H13D5ClN
- Molecular Weight:228.77
IUPAC Name: benzyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-l6-sulfanylidene)-5-oxohexanoate
InChIKey: IYETZZCWLLUHIJ-AAQPRKMGSA-N
SMILES: C#CCN(C)[C@H](C)CC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H].Cl
Biological Activity: Selegiline-d5 (hydrochloride) (Deprenyl-d5 (hydrochloride)) is deuterium labeled Selegiline (hydrochloride). Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder[1][2][3].
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Selegiline-d5 hydrochloride | Selegiline-d5 (hydrochloride) (Deprenyl-d5 (hydrochloride)) is deuterium labeled Selegiline (hydrochloride). Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder. | |||||||||||||||||||||
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Selegiline hydrochloride | 99.94% | Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Chaurasiya ND, et, al. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana). Molecules. 2019 Feb 23;24(4):810. [Content Brief]
- [3]. Tatton WG, et, al. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology. 1996 Dec;47(6 Suppl 3):S171-83. [Content Brief]
