Selegiline hydrochloride (Synonyms: Deprenyl hydrochloride; (-)-Selegiline hydrochloride; (-)-Deprenyl hydrochloride)

Name: Selegiline hydrochloride
Brand: MedChemExpress
SKU: HY-14199
Rating: 5.0 (10 reviews)

Cat. No.: HY-14199 Purity: 99.94%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC₅₀ of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC₅₀=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder.

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CAS No. : 14611-52-0

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	견적 받기
1 g	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 10 publication(s) in Google Scholar

Other Forms of Selegiline hydrochloride:

Selegiline-d₅ hydrochloride 견적 받기
Selegiline 견적 받기

10 Publications Citing Use of MCE Selegiline hydrochloride

In Vivo Efficacy Study

IHC

ELISA

: Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]; Schematic of the experimental timeline for analyzing the effects of the MAO-B inhibitor Selegiline hydrochloride (10 mg/kg, ip, 7 days) on CFA-induced allodynia and NETs formation.

: Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]; Representative blots and quantification of MPO and citH3 in the spinal cords of vehicle, Selegiline hydrochloride, selegiline + CI-amidine, and Selegiline hydrochloride (10 mg/kg, ip, 7 days) + PMA groups.

: Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]; Double immunofluorescence staining for citH3 (red) and MPO (green) in the spinal cords. NETs visualized by colocalization of citH3 and MPO staining (merged images; n = 3, scale bars: 50 or 100 μm). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with the vehicle group mice. #P < 0.05, compared with the Selegiline hydrochloride (10 mg/kg, ip, 7 days) group mice.

: Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]; ELISAs detecting IL-1β, IL-6, and TNF-α in the spinal cords (n = 5, IL-1β: F_{3, 16} = 35.98, P < 0.0001; IL-6: F_{3, 16} = 58.79, P < 0.0001; TNF-α: F_{3, 16} = 155.5, P < 0.0001). The expression levels in the vehicle group were set to 1 for quantification. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with the vehicle group mice. #P < 0.05, compared with the Selegiline hydrochloride (10 mg/kg, ip, 7 days) group mice.

: Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]; Representative blots and quantification of GPR35 in the spinal cords of vehicle, FMD, FMD + Selegiline hydrochloride (10 mg/kg, ip, 7 days), and FMD + 5-HIAA + PMA groups (n = 5, F3, 16 = 23.56, P < 0.0001).

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View All Isoforms

MAO-A MAO-B

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

MAO-B

51 nM (IC₅₀)

In Vitro

Selegiline (1 nM-1 μM) hydrochloride inhibits recombinant human MAO-B in a concentration-dependent manner^[1].
Selegiline (10 mM) hydrochloride increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline hydrochloride inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J mice (20-22 g)^[4]
Dosage:	1 mg/kg
Administration:	I.p. daily for 24 days
Result:	Single injection did not acutely affect mouse locomotor activity. 14 consecutive days administration did not affect food reward. Reduced Cocaine self-administration, and reduced DOPAC and 5-HIAA concentrations in frontal cortex.

분자량

223.74

화학식

C₁₃H₁₈ClN

CAS No.

14611-52-0

Appearance

Solid

Color

White to off-white

SMILES

CN(CC#C)[C@H](C)CC1=CC=CC=C1.Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (446.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 33.33 mg/mL (148.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4695 mL	22.3474 mL	44.6947 mL
5 mM	0.8939 mL	4.4695 mL	8.9389 mL
10 mM	0.4469 mL	2.2347 mL	4.4695 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (22.35 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (22.35 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.96%

Select Batch:

Data Sheet (275 KB) SDS (396 KB)

COA (250 KB) HNMR (260 KB) RP-HPLC (255 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Chaurasiya ND, et, al. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana). Molecules. 2019 Feb 23;24(4):810. [Content Brief]

[2]. Tatton WG, et, al. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology. 1996 Dec;47(6 Suppl 3):S171-83. [Content Brief]

[3]. MohanKumar PS, et, al. Deprenyl stimulates the efflux of monoamines from the rat hypothalamus in vitro. Brain Res Bull. 2001 Apr;54(6):675-80. [Content Brief]

[4]. Ho MC, et, al. Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice. Psychopharmacology (Berl). 2009 Jul;205(1):141-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.4695 mL	22.3474 mL	44.6947 mL	111.7368 mL
	5 mM	0.8939 mL	4.4695 mL	8.9389 mL	22.3474 mL
	10 mM	0.4469 mL	2.2347 mL	4.4695 mL	11.1737 mL
	15 mM	0.2980 mL	1.4898 mL	2.9796 mL	7.4491 mL
	20 mM	0.2235 mL	1.1174 mL	2.2347 mL	5.5868 mL
	25 mM	0.1788 mL	0.8939 mL	1.7878 mL	4.4695 mL
	30 mM	0.1490 mL	0.7449 mL	1.4898 mL	3.7246 mL
	40 mM	0.1117 mL	0.5587 mL	1.1174 mL	2.7934 mL
	50 mM	0.0894 mL	0.4469 mL	0.8939 mL	2.2347 mL
	60 mM	0.0745 mL	0.3725 mL	0.7449 mL	1.8623 mL
	80 mM	0.0559 mL	0.2793 mL	0.5587 mL	1.3967 mL
	100 mM	0.0447 mL	0.2235 mL	0.4469 mL	1.1174 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Selegiline hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selegiline14611-52-0Deprenyl(-)-Selegiline(-)-DeprenylMonoamine OxidaseMAOMAO-BParkinson'sAlzheimer'sdepressiveInhibitorinhibitorinhibit

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Selegiline hydrochloride (Synonyms: Deprenyl hydrochloride; (-)-Selegiline hydrochloride; (-)-Deprenyl hydrochloride)

고객리뷰

Other Forms of Selegiline hydrochloride:

Selegiline hydrochloride Related Antibodies

10 Publications Citing Use of MCE Selegiline hydrochloride

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Monoamine Oxidase Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Selegiline hydrochloride Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Selegiline hydrochloride Related Classifications

Keywords:

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고객리뷰

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SAFETY DATA SHEET (SDS)

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