1253641-15-4
1253641-15-4
Chemical Structure
Glycybenzofuran
- CAS No.: 1253641-15-4
- Formula:C21H22O5
- Molecular Weight:354.40
InChIKey: OEIIVGQLDAYZNT-UHFFFAOYSA-N
SMILES: OC1=CC(OC(C2=C(C=C(C(C/C=C(C)\C)=C2OC)O)O)=C3C)=C3C=C1
Biological Activity: Glycybenzofuran is a flavonoid. Glycybenzofuran can be isolated from G. uralensis. Glycybenzofuran is a potent, competitive, selective PTP1B inhibitor. Glycybenzofuran shows excellent inhibitory selectivity against PTP1B. Glycybenzofuran increases insulin-stimulated pAkt levels. Glycylbenzofuran can be used in the research of hepatocellular carcinoma[1][2].
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Glycybenzofuran | Glycybenzofuran is a flavonoid. Glycybenzofuran can be isolated from G. uralensis. Glycybenzofuran is a potent, competitive, selective PTP1B inhibitor. Glycybenzofuran shows excellent inhibitory selectivity against PTP1B. Glycybenzofuran increases insulin-stimulated pAkt levels. Glycylbenzofuran can be used in the research of hepatocellular carcinoma. | |||||||||||||||||||||
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References
- [1]. Hosseinzadeh H, et al. Pharmacological Effects of Glycyrrhiza spp. and Its Bioactive Constituents: Update and Review. Phytother Res. 2015 Dec;29(12):1868-86. [Content Brief]
- [2]. Li W, et al. Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5836-9. [Content Brief]
Keywords
