1261394-71-1
1261394-71-1
Chemical Structure
Piperaquine-d6
- CAS No.: 1261394-71-1
- Formula:C29H26D6Cl2N6
- Molecular Weight:541.55
IUPAC Name: 4,4'-((propane-1,3-diyl-d6)bis(piperazine-4,1-diyl))bis(7-chloroquinoline)
InChIKey: UCRHFBCYFMIWHC-QLFBILJTSA-N
SMILES: ClC1=CC2=C(C=C1)C(N3CCN(CC3)C([2H])([2H])C([2H])([2H])C([2H])([2H])N4CCN(C5=CC=NC6=C5C=CC(Cl)=C6)CC4)=CC=N2
Biological Activity: Piperaquine-d6 is the deuterium labeled Piperaquine[1]. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[2][3].
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Piperaquine-d6 | Piperaquine-d6 is the deuterium labeled Piperaquine. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin. | |||||||||||||||||||||
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Piperaquine-d6 tetraphosphate | Piperaquine-d6 (tetraphosphate) is the deuterium labeled Piperaquine tetraphosphate. Piperaquine tetraphosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin. | |||||||||||||||||||||
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Piperaquine tetraphosphate | Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. [Content Brief]
- [3]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. [Content Brief]
