1292755-24-8
Chemical Structure
Mouse TREM-1 SCHOOL peptide
Synonym(s): Mouse TREM-1(213–221), GF9
- CAS No.: 1292755-24-8
- Formula:C46H78N10O12
- Molecular Weight:963.17
InChIKey: ZUSCLEXGEXGNHH-CKJCXVCBSA-N
SMILES: OC([C@H](CC1=CC=CC=C1)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets the interaction between TREM-1 and its signaling partner DAP-12, specifically silencing the TREM-1 signaling pathway, regulate the production of TREM-1-mediated pro-inflammatory cytokines in vivo and in vitro. Mouse TREM-1 SCHOOL peptide has anti-tumor effects. Mouse TREM-1 SCHOOL peptide can reduce the formation of vitreoretinal neovascularization[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mouse TREM-1 SCHOOL peptide | 99.91% | Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets the interaction between TREM-1 and its signaling partner DAP-12, specifically silencing the TREM-1 signaling pathway, regulate the production of TREM-1-mediated pro-inflammatory cytokines in vivo and in vitro. Mouse TREM-1 SCHOOL peptide has anti-tumor effects. Mouse TREM-1 SCHOOL peptide can reduce the formation of vitreoretinal neovascularization. | ||||||||||||||||||||
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- [1]. Sigalov AB. A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock. Int Immunopharmacol. 2014 Jul;21(1):208-19. [Content Brief]
- [2]. Rojas MA, et al. Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy. Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2761-2768. [Content Brief]
Keywords
