Mouse TREM-1 SCHOOL peptide
Based on 1 Customer Validation
Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets the interaction between TREM-1 and its signaling partner DAP-12, specifically silencing the TREM-1 signaling pathway, regulate the production of TREM-1-mediated pro-inflammatory cytokines in vivo and in vitro. Mouse TREM-1 SCHOOL peptide has anti-tumor effects. Mouse TREM-1 SCHOOL peptide can reduce the formation of vitreoretinal neovascularization.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 1292755-24-8
- Formula: C46H78N10O12
- Molecular Weight:963.17
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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HY-L025
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HY-L075
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HY-L105
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HY-L001V
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Peptide Compound Library
HY-L105S
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High-Throughput Bioactive Compound Library
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Biological Activity
Mouse TREM-1 SCHOOL peptide reduces the production of inflammatory cytokines in J774 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774
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Concentration:50 ng/mL
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Incubation Time:24 h
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Result:Showed a marked reduction in secreted TNF-α, IL-1β, and IL-6 levels in response to LPS.
Mouse TREM-1 SCHOOL peptide (formulated into a lipopeptide complex (2.5 mg/kg, i.p.)) can prolong the half-life of the peptide and achieve targeted delivery, has a strong anti-angiogenic effect on pathological RNV, and allows physiological neovascularization at the same time in OIR mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:oxygen-induced retinopathy C57BL/6J mice[2]
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Dosage:2.5 mg/kg (HDL-mimicking lipopeptide complexes)
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Administration:Intraperitoneal injection (i.p.)
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Result:Expression of TREM-1 and M-CSF was substantially decreased in oxygen-induced retinopathy (OIR) mice.
Reduced RNV by at least 95% compared with vehicle treatment.
Reduced central avascular area was observed.
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Animal Model:female C57BL/6 mice (8-10 weeks, 18-21 g, injected subcutaneously into the right flanks 5 x 106 H292 or A549 cells per mouse.) induced by LPS (Lipopolysaccharides, from E. coli O55:B5) (HY-D1056)[1]
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Dosage:25, 150, 300 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Showed antitumor efficacy in both models, with the effect more pronounced in the A549 model (31% T/C vs. 52% T/C for the H292 model).
Administration twice a week at a much higher dose of 150 mg/kg did not significantly inhibit tumor growth in both xenograft models.
No weight loss occurred in mice even after a 300 mg/kg dose.
Prolongs survival of mice with LPS-induced septic shock at a dose of 25 mg/kg but contributes to death at a dose of 150 mg/kg.
Chemical Information
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CAS No. 1292755-24-8
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Appearance Solid
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Molecular Weight 963.17
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Formula C46H78N10O12
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Color White to off-white
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Synonyms
Mouse TREM-1(213–221), GF9
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Sequence
Gly-Leu-Leu-Ser-Lys-Ser-Leu-Val-Phe
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Sequence Shortening
GLLSKSLVF
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (103.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sigalov AB. A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock. Int Immunopharmacol. 2014 Jul;21(1):208-19. [Content Brief]
[2]. Rojas MA, et al. Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy. Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2761-2768. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0382 mL | 5.1912 mL | 10.3824 mL | 25.9560 mL |
| 5 mM | 0.2076 mL | 1.0382 mL | 2.0765 mL | 5.1912 mL | |
| 10 mM | 0.1038 mL | 0.5191 mL | 1.0382 mL | 2.5956 mL | |
| 15 mM | 0.0692 mL | 0.3461 mL | 0.6922 mL | 1.7304 mL | |
| 20 mM | 0.0519 mL | 0.2596 mL | 0.5191 mL | 1.2978 mL | |
| 25 mM | 0.0415 mL | 0.2076 mL | 0.4153 mL | 1.0382 mL | |
| 30 mM | 0.0346 mL | 0.1730 mL | 0.3461 mL | 0.8652 mL | |
| 40 mM | 0.0260 mL | 0.1298 mL | 0.2596 mL | 0.6489 mL | |
| 50 mM | 0.0208 mL | 0.1038 mL | 0.2076 mL | 0.5191 mL | |
| 60 mM | 0.0173 mL | 0.0865 mL | 0.1730 mL | 0.4326 mL | |
| 80 mM | 0.0130 mL | 0.0649 mL | 0.1298 mL | 0.3244 mL | |
| 100 mM | 0.0104 mL | 0.0519 mL | 0.1038 mL | 0.2596 mL |
Mouse TREM-1 SCHOOL peptide Related Classifications
HY-P10087 Related Classifications
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