13089-48-0
Chemical Structure
N-Benzoylcytidine
- CAS No.: 13089-48-0
- Formula:C16H17N3O6
- Molecular Weight:347.33
IUPAC Name: N-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
InChIKey: BNXBRFDWSPXODM-BPGGGUHBSA-N
SMILES: O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=CC(NC(C3=CC=CC=C3)=O)=N1
Biological Activity: N-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2). N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos[1][2][3].
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N-Benzoylcytidine | 99.50% | N-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2). N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos. | ||||||||||||||||||||
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- [1]. Van Rompay AR, et al. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6. [Content Brief]
- [2]. Semenyuk A, et al. Synthesis of RNA using 2 ‘-O-DTM protection. Journal of the American Chemical Society, 2006, 128(38): 12356-12357.
- [3]. Shestopalov IA, et al. Light-controlled gene silencing in zebrafish embryos. Nat Chem Biol. 2007 Oct;3(10):650-1. [Content Brief]
Keywords
