1326278-38-9
1326278-38-9
Chemical Structure
Lck-IN-4
- CAS No.: 1326278-38-9
- Formula:C36H43N7O3
- Molecular Weight:621.77
SMILES: CC1=NC=CN2C([C@H]3CC[C@H](N4CCN(CC4)C)CC3)=NC(C5=CC(OC)=C(C=C5)NC(C6=CC7=C(OC)C=CC=C7N6C)=O)=C12
Biological Activity: Lck-IN-4 (Compound A-1) is a protein tyrosine kinase Lck inhibitor with an IC50 of 2 nM. Lck-IN-4 significantly inhibits YAP tyrosine phosphorylation and activity and induces apoptosis in cholangiocarcinoma CCA cells. Lck-IN-4 is cytotoxic in CCA tumor-derived organoids with elevated YAP activity Lck-IN-4 can be used for cancers like cholangiocarcinoma (CCA) research[1].
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Lck-IN-4 | Lck-IN-4 (Compound A-1) is a protein tyrosine kinase Lck inhibitor with an IC50 of 2 nM. Lck-IN-4 significantly inhibits YAP tyrosine phosphorylation and activity and induces apoptosis in cholangiocarcinoma CCA cells. Lck-IN-4 is cytotoxic in CCA tumor-derived organoids with elevated YAP activity Lck-IN-4 can be used for cancers like cholangiocarcinoma (CCA) research. | |||||||||||||||||||||
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References
Keywords
