14114-46-6
Chemical Structure
DMPX
Synonym(s): 3,7-Dimethyl-1-propargylxanthine
- CAS No.: 14114-46-6
- Formula:C10H10N4O2
- Molecular Weight:218.21
IUPAC Name: 3,7-dimethyl-1-(prop-2-yn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
InChIKey: IORPOFJLSIHJOG-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C(N1CC#C)=O)N=CN2C
Biological Activity: DMPX (3,7-Dimethyl-1-propargylxanthine) is a selective A2A adenosine receptor (A2A AR) antagonist that crosses the blood-brain barrier, with a Ki of 11 μM for rat A2 adenosine receptor and a Ki of 45 μM for rat A1 adenosine receptor. By blocking A2A receptors in specific brain regions, DMPX protects dopaminergic and GABAergic neurons from mitochondrial dysfunction. DMPX is applicable to research related to depression, Parkinson's disease and Huntington's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DMPX | 99.66% | DMPX (3,7-Dimethyl-1-propargylxanthine) is a selective A2A adenosine receptor (A2A AR) antagonist that crosses the blood-brain barrier, with a Ki of 11 μM for rat A2 adenosine receptor and a Ki of 45 μM for rat A1 adenosine receptor. By blocking A2A receptors in specific brain regions, DMPX protects dopaminergic and GABAergic neurons from mitochondrial dysfunction. DMPX is applicable to research related to depression, Parkinson's disease and Huntington's disease. | ||||||||||||||||||||
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- [1]. Szopa A, et al. Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist. Pharmacol Rep. 2019;71(4):676-681. [Content Brief]
- [2]. Seale TW, et al. 3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. Life Sci. 1988;43(21):1671-1684. [Content Brief]
- [3]. Alfinito PD, et al. Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. J Neurosci. 2003;23(34):10982-10987. [Content Brief]
Keywords
