1431520-52-3
Chemical Structure
UWA-101 hydrochloride
- CAS No.: 1431520-52-3
- Formula:C13H18ClNO2
- Molecular Weight:255.74
IUPAC Name: 2-(benzo[d][1,3]dioxol-5-yl)-1-cyclopropyl-N-methylethan-1-amine hydrochloride
InChIKey: RTPDALMALRMSMM-UHFFFAOYSA-N
SMILES: CNC(C1CC1)CC2=CC=C3OCOC3=C2.Cl
Biological Activity: UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease[1][2].
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UWA-101 hydrochloride | UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease. | |||||||||||||||||||||
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- [1]. Johnston TH, et al. A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates. FASEB J. 2012 May;26(5):2154-63. [Content Brief]
- [2]. Huot P, et al. Monoamine reuptake inhibitors in Parkinson's disease. Parkinsons Dis. 2015;2015:609428. [Content Brief]
Keywords
