UWA-101 hydrochloride
UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease.
For research use only. We do not sell to patients.
- CAS No.: 1431520-52-3
- Formula: C13H18ClNO2
- Molecular Weight:255.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (250-300 g; Parkinson's disease model)[1].
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Dosage:3 mg/kg
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Administration:Intraperitoneal injection
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Result:Reduced L-DOPA-induced vertical activity by 60%.
Chemical Information
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CAS No. 1431520-52-3
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Molecular Weight 255.74
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Formula C13H18ClNO2
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SMILES
CNC(C1CC1)CC2=CC=C3OCOC3=C2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Johnston TH, et al. A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates. FASEB J. 2012 May;26(5):2154-63. [Content Brief]
[2]. Huot P, et al. Monoamine reuptake inhibitors in Parkinson's disease. Parkinsons Dis. 2015;2015:609428. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UWA-101 hydrochloride Related Classifications
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