1443116-39-9
Chemical Structure
3'-Fluorothymidine-5'-triphosphate tetrasodium
Synonym(s): 3'-FdTTP tetrasodium
- CAS No.: 1443116-39-9
- Formula:C10H12FN2Na4O13P3
- Molecular Weight:572.09
IUPAC Name: sodium ((2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl triphosphate
InChIKey: KSFALXSOBSPBHL-ZKRIHRHSSA-J
SMILES: O=P(O[Na])(O[Na])OP(OP(OC[C@@H]1[C@@H](F)C[C@H](N(C=C(C(N2)=O)C)C2=O)O1)(O[Na])=O)(O[Na])=O
Biological Activity: 3'-Fluorothymidine-5'-triphosphate tetrasodium (3'-FdTTP tetrasodium) is a dTTP (HY-138615) analog. 3'-Fluorothymidine-5'-triphosphate tetrasodium inhibits the T4 DNA polymerases competitively with dTTP. 3'-Fluorothymidine-5'-triphosphate tetrasodium inhibits DNA synthesis by T4 wild-type, L98 and CB121 DNA polymerase[1][2].
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3'-Fluorothymidine-5'-triphosphate tetrasodium | 99.94% | 3'-Fluorothymidine-5'-triphosphate tetrasodium (3'-FdTTP tetrasodium) is a dTTP (HY-138615) analog. 3'-Fluorothymidine-5'-triphosphate tetrasodium inhibits the T4 DNA polymerases competitively with dTTP. 3'-Fluorothymidine-5'-triphosphate tetrasodium inhibits DNA synthesis by T4 wild-type, L98 and CB121 DNA polymerase. | ||||||||||||||||||||
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- [1]. Schroeder C, et al. Inhibitor studies on phage T4 wild-type and mutant DNA polymerase. IV. The substrate analog 3'-fluorothymidine 5'-triphosphate. Z Allg Mikrobiol. 1980;20(10):657-62. [Content Brief]
- [2]. Schroeder C, et al.Inhibitor studies of phage T4 wild‐type and mutant DNA polymerases V. A summary of kinetic and inhibition data. Zeitschrift für allgemeine Mikrobiologie, 1981, 21(2): 141-155.
