1447811-26-8
Chemical Structure
EVP-0015962
- CAS No.: 1447811-26-8
- Formula:C22H19ClF6O3
- Molecular Weight:480.83
IUPAC Name: (R)-2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-3-cyclobutylpropanoic acid
InChIKey: ZSERTYLZGRJLOO-QGZVFWFLSA-N
SMILES: O=C([C@@H](C1=CC(C2=CC=C(C=C2)C(F)(F)F)=C(C(Cl)=C1)OCC(F)(F)F)CC3CCC3)O
Biological Activity: EVP-0015962 is an orally active, blood-brain barrier-permeable γ-secretase inhibitor with an IC50 of 3.9 μM. EVP-0015962 alters γ-secretase-mediated cleavage of amyloid precursor protein, reduces Aβ42 production and increases Aβ38 production. EVP-0015962 reduces Aβ aggregates, amyloid plaques and inflammatory markers in the brains of mice, and improves their cognitive impairment. EVP-0015962 can be used for the research of Alzheimer's disease[1].
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EVP-0015962 | EVP-0015962 is an orally active, blood-brain barrier-permeable γ-secretase inhibitor with an IC50 of 3.9 μM. EVP-0015962 alters γ-secretase-mediated cleavage of amyloid precursor protein, reduces Aβ42 production and increases Aβ38 production. EVP-0015962 reduces Aβ aggregates, amyloid plaques and inflammatory markers in the brains of mice, and improves their cognitive impairment. EVP-0015962 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
