145815-98-1
Chemical Structure
Icopezil maleate
Synonym(s): CP-118954 maleate
- No. CAS: 145815-98-1
- Formula:C27H29N3O6
- Molecular Weight:491.54
IUPAC Name: 3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,7-dihydro-6H-isoxazolo[4,5-f]indol-6-one maleate
InChIKey: CTYSKGVFLJLGGX-BTJKTKAUSA-N
SMILES: OC(/C=C\C(O)=O)=O.O=C1CC2=CC(C(CCC3CCN(CC3)CC4=CC=CC=C4)=NO5)=C5C=C2N1
Biological Activity: Icopezil maleate (CP-118954 maleate) is an orally active, selective AchE inhibitor with an IC50 of 0.33 nM. Icopezil maleate increases acetylcholine levels in the brain and striatum of mammals, induces centrally mediated tremors and peripherally mediated salivation, and improves working memory performance in aged dogs. Icopezil maleate serves as a parent compound for radioiodine-labeled acetylcholinesterase imaging agents. Icopezil maleate is applicable to research related to Alzheimer's disease[1][2][3][4].
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Icopezil maleate | Icopezil maleate (CP-118954 maleate) is an orally active, selective AchE inhibitor with an IC50 of 0.33 nM. Icopezil maleate increases acetylcholine levels in the brain and striatum of mammals, induces centrally mediated tremors and peripherally mediated salivation, and improves working memory performance in aged dogs. Icopezil maleate serves as a parent compound for radioiodine-labeled acetylcholinesterase imaging agents. Icopezil maleate is applicable to research related to Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Liston DR, et al. Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. European journal of pharmacology. 2004 Feb 13;486(1):9-17. [Content Brief]
- [2]. Studzinski CM, et al. The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Progress in neuro-psychopharmacology & biological psychiatry. 2005 Mar;29(3):489-98. [Content Brief]
- [3]. Muñoz-Torrero D, et al. Dimeric and hybrid anti-Alzheimer drug candidates. Current medicinal chemistry. 2006;13(4):399-422. [Content Brief]
- [4]. Lee I, et al. Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase. Nucl Med Commun. 2007 Jul;28(7):561-6. [Content Brief]
Keywords
