146062-45-5
146062-45-5
Chemical Structure
Ketopioglitazone
- CAS No.: 146062-45-5
- Formula:C19H18N2O4S
- Molecular Weight:370.42
IUPAC Name: 5-(4-(2-(5-acetylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
InChIKey: JMLKLMFMQRAJNI-UHFFFAOYSA-N
SMILES: O=C(SC1CC2=CC=C(C=C2)OCCC3=NC=C(C=C3)C(C)=O)NC1=O
Biological Activity: Pioglitazone ketone is an active metabolite of the PPARγ agonist Pioglitazone (HY-13956). Formation of pioglitazone ketone occurs primarly through cytochrome P450 (CYP) isoform CYP2C8-mediated metabolism of pioglitazone. Pioglitazone ketone (100 mg/kg in the diet) reduces blood glucose levels in a KKAy mouse model of type 2 diabetes.
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Ketopioglitazone | Pioglitazone ketone is an active metabolite of the PPARγ agonist Pioglitazone (HY-13956). Formation of pioglitazone ketone occurs primarly through cytochrome P450 (CYP) isoform CYP2C8-mediated metabolism of pioglitazone. Pioglitazone ketone (100 mg/kg in the diet) reduces blood glucose levels in a KKAy mouse model of type 2 diabetes. | |||||||||||||||||||||
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Ketopioglitazone-d4 | Ketopioglitazone-d4 is deuterium labeled Ketopioglitazone. | |||||||||||||||||||||
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Keto Pioglitazone-d4 (M-III-d4) | Keto Pioglitazone-d4 (M-III-d4) is the deuterium labeled Keto Pioglitazone (M-III). | |||||||||||||||||||||
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