149394-65-0
149394-65-0
Chemical Structure
U-96988
Synonym(s): PNU-96988
- CAS No.: 149394-65-0
- Formula:C24H26O3
- Molecular Weight:362.46
IUPAC Name: 4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl)-2H-pyran-2-one
InChIKey: HALPINAQGOXQAN-UHFFFAOYSA-N
SMILES: O=C1C(C(C2=CC=CC=C2)CC)=C(O)C=C(C(CC3=CC=CC=C3)CC)O1
Biological Activity: U-96988 (PNU-96988) is a non-peptide HIV-1 protease inhibitor with a Ki value of 38 nM. U-96988 is also effective against HIV-2 protease. U-96988 exhibits an IC50 for HIV-1IIIB of 5 μM. U-96988 can be used for research on HIV infection[1][2].
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U-96988 | U-96988 (PNU-96988) is a non-peptide HIV-1 protease inhibitor with a Ki value of 38 nM. U-96988 is also effective against HIV-2 protease. U-96988 exhibits an IC50 for HIV-1IIIB of 5 μM. U-96988 can be used for research on HIV infection. | |||||||||||||||||||||
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References
- [1]. Koeplinger KA, et al. Equilibrium distribution of HIV antiviral drugs into human peripheral blood mononuclear cells (PBMC) is controlled by free drug concentration in the extracellular medium. J Pharm Biomed Anal. 1999 Mar;19(3-4):399-411. [Content Brief]
- [2]. Thaisrivongs S, et al. Structure-based design of HIV protease inhibitors: 5,6-dihydro-4-hydroxy-2-pyrones as effective, nonpeptidic inhibitors. J Med Chem. 1996 Nov 8;39(23):4630-42. [Content Brief]
Keywords
