2. Anti-infection Metabolic Enzyme/Protease
  3. HIV HIV Protease
  4. U-96988

U-96988 (PNU-96988) is a non-peptide HIV-1 protease inhibitor with a Ki value of 38 nM. U-96988 is also effective against HIV-2 protease. U-96988 exhibits an IC50 for HIV-1IIIB of 5 μM. U-96988 can be used for research on HIV infection.

For research use only. We do not sell to patients.

U-96988

U-96988 Chemical Structure

CAS No. : 149394-65-0

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U-96988 Related Antibodies

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Description

U-96988 (PNU-96988) is a non-peptide HIV-1 protease inhibitor with a Ki value of 38 nM. U-96988 is also effective against HIV-2 protease. U-96988 exhibits an IC50 for HIV-1IIIB of 5 μM. U-96988 can be used for research on HIV infection[1][2].

Cellular Effect
Cell Line Type Value Description References
H9 ED50
3 μM
Compound: 7
Tested for the antiviral activity against HIV-1 IIIB-infected H9 cells
Tested for the antiviral activity against HIV-1 IIIB-infected H9 cells
[PMID: 7932546]
MT4 ED50
3 μM
Compound: 7
Tested for the antiviral activity against HIV-1 IIIB-infected MT-4
Tested for the antiviral activity against HIV-1 IIIB-infected MT-4
[PMID: 7932546]
Molecular Weight

362.46

Formula

C24H26O3
CAS No.
SMILES

O=C1C(C(C2=CC=CC=C2)CC)=C(O)C=C(C(CC3=CC=CC=C3)CC)O1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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U-96988 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-96988149394-65-0PNU-96988U96988U 96988PNU96988PNU 96988HIVHIV ProteaseHuman immunodeficiency virusprotein bindingfree drug concentrationperipheral blood mononuclear cells (PBMC)equilibrium distributionantiviral activityserum effectstructure-based designInhibitorinhibitorinhibit

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