U-96988
U-96988 (PNU-96988) is a non-peptide HIV-1 protease inhibitor with a Ki value of 38 nM. U-96988 is also effective against HIV-2 protease. U-96988 exhibits an IC50 for HIV-1IIIB of 5 μM. U-96988 can be used for research on HIV infection.
For research use only. We do not sell to patients.
- CAS No.: 149394-65-0
- Formula: C24H26O3
- Molecular Weight:362.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9 | ED50 |
3 μM
Compound: 7
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Tested for the antiviral activity against HIV-1 IIIB-infected H9 cells
Tested for the antiviral activity against HIV-1 IIIB-infected H9 cells
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[PMID: 7932546] |
| MT4 | ED50 |
3 μM
Compound: 7
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Tested for the antiviral activity against HIV-1 IIIB-infected MT-4
Tested for the antiviral activity against HIV-1 IIIB-infected MT-4
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[PMID: 7932546] |
Chemical Information
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CAS No. 149394-65-0
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Molecular Weight 362.46
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Formula C24H26O3
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SMILES
O=C1C(C(C2=CC=CC=C2)CC)=C(O)C=C(C(CC3=CC=CC=C3)CC)O1
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Synonyms
PNU-96988
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Koeplinger KA, et al. Equilibrium distribution of HIV antiviral drugs into human peripheral blood mononuclear cells (PBMC) is controlled by free drug concentration in the extracellular medium. J Pharm Biomed Anal. 1999 Mar;19(3-4):399-411. [Content Brief]
[2]. Thaisrivongs S, et al. Structure-based design of HIV protease inhibitors: 5,6-dihydro-4-hydroxy-2-pyrones as effective, nonpeptidic inhibitors. J Med Chem. 1996 Nov 8;39(23):4630-42. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U-96988 Related Classifications
HY-19215 Related Classifications
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