1557206-59-3
Chemical Structure
BMS-884775
- CAS No.: 1557206-59-3
- Formula:C36H35ClF2N6O2S
- Molecular Weight:689.22
IUPAC Name: 1-(5-chlorothiazolo[5,4-b]pyridin-2-yl)-3-(2-(5-fluoro-4-(4-fluorophenyl)-7-hydroxy-1'-neopentylspiro[indoline-3,4'-piperidin]-1-yl)phenyl)urea
InChIKey: MEOSYRMQDNYEEI-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=CC=C(Cl)N=C2S1)NC3=CC=CC=C3N4CC5(CCN(CC(C)(C)C)CC5)C6=C4C(O)=CC(F)=C6C7=CC=C(F)C=C7
Biological Activity: BMS-884775 is a selective and orally active P2Y1 antagonist with an IC50 of 0.1 nM for the human P2Y1 receptor. BMS-884775 has a similar efficacy in preventing arterial thrombosis to Clopidogrel (HY-15283) and Prasugrel (HY-15284), but treatment with BMS-884775 results in shorter bleeding time and lower bleeding risk. BMS-884775 can be used in research related to antiplatelet and arterial thrombosis-associated diseases[1][2].
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BMS-884775 | BMS-884775 is a selective and orally active P2Y1 antagonist with an IC50 of 0.1 nM for the human P2Y1 receptor. BMS-884775 has a similar efficacy in preventing arterial thrombosis to Clopidogrel (HY-15283) and Prasugrel (HY-15284), but treatment with BMS-884775 results in shorter bleeding time and lower bleeding risk. BMS-884775 can be used in research related to antiplatelet and arterial thrombosis-associated diseases. | |||||||||||||||||||||
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- [1]. Wong P, et al. Differential effects of P2Y1 versus P2Y12 receptor antagonism on thrombosis and bleeding in rabbits. European Heart Journal, 2013, 34(suppl_1): P1431.
- [2]. Tscharre M, et al. Novel Antiplatelet Agents in Cardiovascular Disease. J Cardiovasc Pharmacol Ther. 2020 May;25(3):191-200. [Content Brief]
Keywords
