1776116-75-6
1776116-75-6
Chemical Structure
MC2625
- CAS No.: 1776116-75-6
- Formula:C23H21N3O3
- Molecular Weight:387.43
IUPAC Name: (E)-3-(5-(2,3-diphenylpropanamido)pyridin-2-yl)-N-hydroxyacrylamide
InChIKey: UQSIPNLHOWORHA-BUHFOSPRSA-N
SMILES: O=C(NO)/C=C/C1=NC=C(C=C1)NC(C(C2=CC=CC=C2)CC3=CC=CC=C3)=O
Biological Activity: MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC50s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction[1][2].
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MC2625 | MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC50s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction. | |||||||||||||||||||||
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References
- [1]. Gemma Di Pompo, et al. Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J Med Chem. 2015 May 14;58(9):4073-9. [Content Brief]
- [2]. Elisabetta Di Bello, et al. Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells. Eur J Med Chem. 2022 Dec 15;247:115022. [Content Brief]
Keywords
