1824647-09-7
1824647-09-7
Chemical Structure
Smurf1-IN-5
- CAS No.: 1824647-09-7
- Formula:C25H22ClFN4O3
- Molecular Weight:480.92
InChIKey: YCHGQICUQDEGMP-UHFFFAOYSA-N
SMILES: FC1=CC=CC=C1N2C(C(NC(C3=NOC(C4=CC=C(C5CC5)C=C4Cl)=C3C)=O)=C(C)N2C)=O
Biological Activity: Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH)[1].
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Smurf1-IN-5 | Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH). | |||||||||||||||||||||
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References
Keywords
