182912-74-9
Chemical Structure
β-Sheet Breaker Peptide iAβ5
Synonym(s): [Pro18, Asp21] β-Amyloid (17-21)
- CAS No.: 182912-74-9
- Formula:C33H43N5O8
- Molecular Weight:637.72
IUPAC Name: L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-aspartic acid
InChIKey: RALAXQOLLAQGTI-IRGGMKSGSA-N
SMILES: OC(C[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@@H](N)CC(C)C)=O)=O)=O)=O)=O
Biological Activity: β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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β-Sheet Breaker Peptide iAβ5 | 98.64% | β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination. | ||||||||||||||||||||
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