1854008-12-0
Chemical Structure
VSP-77
- CAS No.: 1854008-12-0
- Formula:C16H23ClO3
- Molecular Weight:298.81
IUPAC Name: 2-((1-(4-chlorophenyl)octyl)oxy)acetic acid
InChIKey: AYARWYQDJCOTIK-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C(CCCCCCC)OCC(O)=O)C=C1
Biological Activity: VSP-77 is an orally active PPARγ agonist. VSP-77 selectively upregulates the expression of insulin sensitivity-related genes (Glut4 and Adiponectin) by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. VSP-77 significantly improves glucose tolerance, reduces fasting blood glucose and insulin levels in high-fat diet (HFD)-induced diabetic mouse models. VSP-77 can be used for the study of diabetes[1].
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VSP-77 | VSP-77 is an orally active PPARγ agonist. VSP-77 selectively upregulates the expression of insulin sensitivity-related genes (Glut4 and Adiponectin) by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. VSP-77 significantly improves glucose tolerance, reduces fasting blood glucose and insulin levels in high-fat diet (HFD)-induced diabetic mouse models. VSP-77 can be used for the study of diabetes. | |||||||||||||||||||||
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Keywords
