1927024-52-9
Chemical Structure
Uralione D
- CAS No.: 1927024-52-9
- Formula:C38H52O7
- Molecular Weight:620.82
IUPAC Name: (3S,6S,8S,9R,10S)-10-benzoyl-6-((S)-2,3-dihydroxy-3-methylbutyl)-3-hydroxy-2,2,9-trimethyl-8-(3-methylbut-2-en-1-yl)-9-(4-methylpent-3-en-1-yl)-2,3,4,6,7,8,9,10-octahydro-5H-6,10-methanocycloocta[b]pyran-5,11-dione
InChIKey: RDDUKJQVZHWJAA-KGYLDTGXSA-N
SMILES: O=C(C1=CC=CC=C1)[C@]23C4=C(C[C@@H](C(C)(O4)C)O)C([C@](C2=O)(C[C@@H]([C@@]3(C)CC/C=C(C)/C)C/C=C(C)\C)C[C@H](O)C(C)(O)C)=O
Biological Activity: Uralione D is a neuroprotective agent found in Hypericum uralum and Hypericum kouytchense. Uralione D exhibits cytotoxic activity against gastric cancer cells and protects against Corticosterone (HY-B1618)-induced damage in neuron-like cells. Uralione D is useful for research on depression, multidrug-resistant liver cancer, and gastric cancer[1][2][3].
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Uralione D | Uralione D is a neuroprotective agent found in Hypericum uralum and Hypericum kouytchense. Uralione D exhibits cytotoxic activity against gastric cancer cells and protects against Corticosterone (HY-B1618)-induced damage in neuron-like cells. Uralione D is useful for research on depression, multidrug-resistant liver cancer, and gastric cancer. | |||||||||||||||||||||
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References
- [1]. Zhou ZB, et al. Polycyclic Polyprenylated Derivatives from Hypericum uralum: Neuroprotective Effects and Antidepressant-like Activity of Uralodin A. Journal of natural products. 2016 May 27;79(5):1231-40.
- [2]. Lou HY, et al. Hyperkouytones A-O, new polyprenylated acylphloroglucinols from Hypericum kouytchense with multidrug resistance reversal activity. Chin J Chem. 2024;42(24):3293-3307.
- [3]. Jing C, et al. Polycyclic polyprenylated acylphloroglucinols (PPAPs) kouytchin A‑B and a tetramethoxydibenzo[1,4]dioxin from Hypericum kouytchense: isolation and cytotoxic evaluation. ChemistrySelect. 2026;11(1):e04003.
