2098211-50-6
2098211-50-6
Chemical Structure
I-138
- CAS No.: 2098211-50-6
- Formula:C26H23F3N6O
- Molecular Weight:492.50
IUPAC Name: 2-(2-isopropylphenyl)-9-(4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-7,9-dihydro-8H-purin-8-one
InChIKey: MVCJEDLGJGHLJM-UHFFFAOYSA-N
SMILES: O=C1NC2=CN=C(C3=CC=CC=C3C(C)C)N=C2N1CC4=CC=C(C5=NC(C(F)(F)F)=CN5C)C=C4
Biological Activity: I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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I-138 | 99.75% | I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells. | ||||||||||||||||||||
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References
Keywords
