215297-27-1
215297-27-1
Chemical Structure
UK 343664
- CAS No.: 215297-27-1
- Formula:C28H35N7O4S
- Molecular Weight:565.69
IUPAC Name: 3-ethyl-5-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-propoxyphenyl)-2-(pyridin-2-ylmethyl)-2,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
InChIKey: NIBCDDKWFDEBEP-UHFFFAOYSA-N
SMILES: O=C1N=C(C2=C(OCCC)C=CC(S(=O)(N3CCN(CC3)CC)=O)=C2)NC4=C(CC)N(CC5=NC=CC=C5)N=C41
Biological Activity: UK 343664 is a potent, orally active and selective PDE5 inhibitor. UK 343664 partially reverses Thromboxane-induced pulmonary hypertension[1][2].
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UK 343664 | UK 343664 is a potent, orally active and selective PDE5 inhibitor. UK 343664 partially reverses Thromboxane-induced pulmonary hypertension. | |||||||||||||||||||||
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References
- [1]. Walker DK, et al. Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog. Xenobiotica. 2001 Aug-Sep;31(8-9):651-64. [Content Brief]
- [2]. Urdaneta F, et al. Effects of a new phosphodiesterase enzyme type V inhibitor (UK 343-664) versus milrinone in a porcine model of acute pulmonary hypertension. Ann Thorac Surg. 2004 Oct;78(4):1433-7. [Content Brief]
Keywords
