2169267-60-9
Chemical Structure
MR-39
- CAS. Nr.: 2169267-60-9
- Formula:C27H23ClF2N4O2
- Molecular Weight:508.95
InChIKey: LIRJUPFMKLVNMO-DEOSSOPVSA-N
SMILES: FC1=CC=C(NC(N[C@@H](CC2=CC=C(C#N)C=C2)C(NCC3(CC3)C4=CC(Cl)=C(F)C=C4)=O)=O)C=C1
Biological Activity: MR-39 is a FPR2 agonist (EC50 = 3.9 μM). MR-39 activates FPR2 to promote neuroinflammation resolution (downregulates IL-1β and TNF-α, modulates NF-κB), upregulates synaptic proteins (synaptic proteins) and improves dendritic spine morphology. MR-39 inhibits MAPK/ERK and AKT phosphorylation in glioblastoma, induces S-phase arrest, and suppresses migration, angiogenesis, and hypoxic adaptation. MR-39 reduces Aβ plaque burden via inhibiting MyD88/NF-κB and NLRP3 inflammasome. MR-39 can be used for research on autism spectrum disorder, Alzheimer's disease, and glioblastoma[1][2][3][4].
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MR-39 | MR-39 is a FPR2 agonist (EC50 = 3.9 μM). MR-39 activates FPR2 to promote neuroinflammation resolution (downregulates IL-1β and TNF-α, modulates NF-κB), upregulates synaptic proteins (synaptic proteins) and improves dendritic spine morphology. MR-39 inhibits MAPK/ERK and AKT phosphorylation in glioblastoma, induces S-phase arrest, and suppresses migration, angiogenesis, and hypoxic adaptation. MR-39 reduces Aβ plaque burden via inhibiting MyD88/NF-κB and NLRP3 inflammasome. MR-39 can be used for research on autism spectrum disorder, Alzheimer's disease, and glioblastoma. | |||||||||||||||||||||
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- [1]. Vitone, et al. Toward a Therapy for Autism Spectrum Disorder: The Formyl Peptide Receptor 2 Agonist MR-39 Supports Synaptic Health in the BTBR Mouse and Features a Favorable Safety Profile. ACS Pharmacology & Translational Science. 2026 June 24.
- [2]. Ferraro MG, et al. Formyl peptide receptor 2 activation by MR-39 inhibits glioblastoma cell proliferation and invasiveness through suppression of multiple oncogenic pathways. J Transl Med. 2026 Feb 6;24(1):342. [Content Brief]
- [3]. Cristiano C, et al. Behavioral, Anti-Inflammatory, and Neuroprotective Effects of a Novel FPR2 Agonist in Two Mouse Models of Autism. Pharmaceuticals (Basel). 2022 Jan 28;15(2):161. [Content Brief]
- [4]. Trojan E, et al. The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1-42)-Induced Neuroinflammation in Mouse Models of Alzheimer's Disease. Mol Neurobiol. 2021 Dec;58(12):6203-6221. [Content Brief]
Keywords
