2169278-81-1
Chemical Structure
Hsp90-IN-40
- CAS No.: 2169278-81-1
- Formula:C33H40N2O4
- Molecular Weight:528.68
SMILES: COC1=C(C2=CC(OC)=CC=C2)C=C(C=C1)C(N[C@@H]3CC[C@H](C4=CC=C(C=C4)OC5CCN(CC5)C)CC3)=O
Biological Activity: Hsp90-IN-40 (Compound 15b) is a heat shock protein 90 (Hsp90) C-terminal inhibitor. Hsp90-IN-40 exhibits antiproliferative activity against SKBr3 and MCF-7 breast cancer cells (IC50 of 2.57 µM and 2.43 µM, respectively). Hsp90-IN-40 inhibits cancer cell growth by inhibiting the Hsp90 C-terminal function, leading to Hsp90-dependent protein degradation. Hsp90-IN-40 can be used in breast cancer research[1].
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Hsp90-IN-40 | Hsp90-IN-40 (Compound 15b) is a heat shock protein 90 (Hsp90) C-terminal inhibitor. Hsp90-IN-40 exhibits antiproliferative activity against SKBr3 and MCF-7 breast cancer cells (IC50 of 2.57 µM and 2.43 µM, respectively). Hsp90-IN-40 inhibits cancer cell growth by inhibiting the Hsp90 C-terminal function, leading to Hsp90-dependent protein degradation. Hsp90-IN-40 can be used in breast cancer research. | |||||||||||||||||||||
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Keywords
