2193085-94-6

NCGC1481 Chemical Structure
2193085-94-6

Chemical Structure

NCGC1481

  • No. CAS: 2193085-94-6
  • Formula:C21H23N7O
  • Molecular Weight:389.45

InChIKey: IALDYVNFZAPNJV-UHFFFAOYSA-N

SMILES: CN1N=CC(C2=CN3C(C=C2OC)=NC=C3C4=CC=CC(NC5CNCC5)=N4)=C1

Biological Activity: NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity[1].

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HY-160787 		NCGC1481 NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity.
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