2206660-94-6
Chemical Structure
Zopocianine
Synonym(s): OTL-0078; OTL78
- CAS No.: 2206660-94-6
- Formula:C74H93N7O27S4
- Molecular Weight:1640.82
InChIKey: KPIFKEKRKCVGMU-HQOHQVRUSA-N
SMILES: O=S(CCCCN1C2=CC=C(S(=O)(O)=O)C=C2C(C)(/C1=C/C=C3C(OC4=CC=C(C=C4)C[C@@H](C(O)=O)NC([C@@H](NC(CCOCCOCCNC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=C(CCC/3)/C=C\C6=[N+](C7=CC=C(S(=O)(O)=O)C=C7C6(C)C)CCCCS(=O)([O-])=O)C)(O)=O
Biological Activity: Zopocianine (OTL-0078; OTL78) is a near-infrared optical probe targeting PSMA. Zopocianine binds to PSMA on the surface of PSMA-expressing cells, enters cells via receptor-mediated endocytosis, and accumulates in acidic endosomes. Zopocianine selectively accumulates in PSMA-positive cancer tissues and enables the detection of small tumors, primary prostate tumors, and locoregional metastases. Zopocianine helps achieve negative tumor surgical margins during fluorescence-guided surgery. Zopocianine is applicable to research related to prostate cancer[1].
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Zopocianine | 98.12% | Zopocianine (OTL-0078; OTL78) is a near-infrared optical probe targeting PSMA. Zopocianine binds to PSMA on the surface of PSMA-expressing cells, enters cells via receptor-mediated endocytosis, and accumulates in acidic endosomes. Zopocianine selectively accumulates in PSMA-positive cancer tissues and enables the detection of small tumors, primary prostate tumors, and locoregional metastases. Zopocianine helps achieve negative tumor surgical margins during fluorescence-guided surgery. Zopocianine is applicable to research related to prostate cancer. | ||||||||||||||||||||
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Keywords
