Zopocianine
Based on 1 Customer Validation
Zopocianine (OTL-0078; OTL78) is a near-infrared optical probe targeting PSMA. Zopocianine binds to PSMA on the surface of PSMA-expressing cells, enters cells via receptor-mediated endocytosis, and accumulates in acidic endosomes. Zopocianine selectively accumulates in PSMA-positive cancer tissues and enables the detection of small tumors, primary prostate tumors, and locoregional metastases. Zopocianine helps achieve negative tumor surgical margins during fluorescence-guided surgery. Zopocianine is applicable to research related to prostate cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.12%
- CAS. Nr.: 2206660-94-6
- Formel: C74H93N7O27S4
- Molecular Weight:1640.82
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Zopocianine (0.001 nmol/L-10 μmol/L; 30 min at 4°C) competes for PSMA binding on 22Rv1 human prostate cancer cells with an IC50 of 7 nmol/L[1].
Zopocianine (0-120 nmol/L; 30 min at 4°C) binds directly to PSMA+ 22Rv1 human prostate cancer cells with a Kd of 4.7 nmol/L, and shows no significant binding to PSMA- PC3 human prostate cancer cells[1].
Zopocianine (100 nmol/L; 1 h at 37°C, 1 h at 4°C) binds to the cell surface of PSMA+ 22Rv1 and LNCaP human prostate cancer cells at 4°C, and undergoes PSMA-mediated internalization into acidic endosomes at 37°C, with no detectable binding to PSMA- PC3 human prostate cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | T1/2 |
|---|---|---|---|
| Mice[1] | 10 nM | i.v. | ~17 min |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:nu/nu (nude) (7-week-old, male; subcutaneous xenograft model with 22Rv1 cells)/SCID (7-week-old, male; orthotopic xenograft model with 22Rv1 cells)[1]
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Dosage:0.3 nM/mouse, 1 nM/mouse, 3 nM/mouse, 10 nM/mouse, 30 nM/mouse, 120 nM/mouse
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Administration:i.v.; single bolus injection
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Result:Provided an excellent tumor-to-background ratio (TBR) and accumulates within orthotopic prostate tumors.
Enabled fluorescence-guided surgery, achieving a 100% tumor-free survival rate at 30 days, with no observed biochemical recurrence.
Generated high-quality tumor images.
Chemical Information
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CAS. Nr. 2206660-94-6
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Appearance Solid
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Molecular Weight 1640.82
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Formel C74H93N7O27S4
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Color Green to dark green
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SMILES
O=S(CCCCN1C2=CC=C(S(=O)(O)=O)C=C2C(C)(/C1=C/C=C3C(OC4=CC=C(C=C4)C[C@@H](C(O)=O)NC([C@@H](NC(CCOCCOCCNC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=C(CCC/3)/C=C\C6=[N+](C7=CC=C(S(=O)(O)=O)C=C7C6(C)C)CCCCS(=O)([O-])=O)C)(O)=O
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Synonyms
OTL-0078; OTL78
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 5 mg/mL (3.05 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6095 mL | 3.0473 mL | 6.0945 mL | 15.2363 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Zopocianine Related Classifications
HY-159500 Related Classifications
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