2226557-15-7
2226557-15-7
Chemical Structure
αvβ5 integrin-IN-3
- CAS No.: 2226557-15-7
- Formula:C22H26N6O2
- Molecular Weight:406.48
InChIKey: ZKJMYZGFBDUOAC-FQEVSTJZSA-N
SMILES: OC(C[C@@H](C1=CN=C(C)N=C1)N2C=CC(CCCC3=NC(NCCC4)=C4C=C3)=N2)=O
Biological Activity: αvβ5 integrin-IN-3 is an orally active, selective αVβ5 integrin inhibitor with an IC50 value of 0.61 nM. αvβ5 integrin-IN-3 inhibits αVβ1, αVβ3 and αVβ6 integrins with IC50 values of 21 nM, 5.5 nM and 18 nM, respectively. αvβ5 integrin-IN-3 reduces total Collagen content in a mouse unilateral ureteral obstruction model. αvβ5 integrin-IN-3 can be used for the research of renal fibrosis[1].
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αvβ5 integrin-IN-3 | αvβ5 integrin-IN-3 is an orally active, selective αVβ5 integrin inhibitor with an IC50 value of 0.61 nM. αvβ5 integrin-IN-3 inhibits αVβ1, αVβ3 and αVβ6 integrins with IC50 values of 21 nM, 5.5 nM and 18 nM, respectively. αvβ5 integrin-IN-3 reduces total Collagen content in a mouse unilateral ureteral obstruction model. αvβ5 integrin-IN-3 can be used for the research of renal fibrosis. | |||||||||||||||||||||
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