2241232-43-7
2241232-43-7
Chemical Structure
Hu7691 free base
- CAS No.: 2241232-43-7
- Formula:C22H21F3N4O
- Molecular Weight:414.42
IUPAC Name: N-((3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide
InChIKey: PALTUSLCLFDFQQ-MGPUTAFESA-N
SMILES: O=C(N[C@@H]1CNCC[C@H]1C2=CC=C(F)C(F)=C2)C3=CC=C(C4=CC=NN4C)C=C3F
Biological Activity: Hu7691 free base is an orally active, selective Akt inhibitor with IC50s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice[1].
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Hu7691 free base | Hu7691 free base is an orally active, selective Akt inhibitor with IC50s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice. | |||||||||||||||||||||
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References
Keywords
