2244678-29-1
Chemical Structure
TH-257
- CAS No.: 2244678-29-1
- Formula:C24H26N2O3S
- Molecular Weight:422.54
IUPAC Name: N-benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide
InChIKey: VNCIWNGCMAKKEO-UHFFFAOYSA-N
SMILES: O=C(N(CCCC)CC1=CC=CC=C1)C2=CC=C(S(=O)(NC3=CC=CC=C3)=O)C=C2
Biological Activity: TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TH-257 | 98.36% | TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM. | ||||||||||||||||||||
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Keywords
