1. Cell Cycle/DNA Damage
  2. LIM Kinase (LIMK)
  3. TH-257

TH-257 

Cat. No.: HY-122630
Handling Instructions

TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM.

For research use only. We do not sell to patients.

TH-257 Chemical Structure

TH-257 Chemical Structure

CAS No. : 2244678-29-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 73 In-stock
Estimated Time of Arrival: December 31
10 mg USD 113 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1].

IC50 & Target[1]

LIMK1

84 nM (IC50)

LIMK2

39 nM (IC50)

Molecular Weight

422.54

Formula

C₂₄H₂₆N₂O₃S

CAS No.

2244678-29-1

SMILES

O=C(N(CCCC)CC1=CC=CC=C1)C2=CC=C(S(=O)(NC3=CC=CC=C3)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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TH-257
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HY-122630
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