2351218-88-5
Chemical Structure
dMCL1-2
- CAS No.: 2351218-88-5
- Formula:C61H66N10O12S
- Molecular Weight:1163.30
IUPAC Name: 7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)ethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid
InChIKey: VPWUIQNEJHXPSK-UHFFFAOYSA-N
SMILES: O=S(N(CC1)CCN1C(C=C2)=CC=C2OCC3=C(C4=C(N(CCN5CCN(C(COC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)CC5)C(C(O)=O)=C9CCCOC%10=C(C=CC=C%11)C%11=CC=C%10)C9=CC=C4)C(C)=NN3C)(N(C)C)=O
Biological Activity: dMCL1-2 is a potent, selective MCL1 PROTAC degrader based on a Cereblon ligand, with a KD value of 30 nM for binding to MCL1. dMCL1-2 induces ubiquitination and degradation of MCL1. dMCL1-2 degrades MCL1, cleaves Caspase-3, and induces Apoptosis. dMCL1-2 can be used in research related to multiple myeloma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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dMCL1-2 | 99.29% | dMCL1-2 is a potent, selective MCL1 PROTAC degrader based on a Cereblon ligand, with a KD value of 30 nM for binding to MCL1. dMCL1-2 induces ubiquitination and degradation of MCL1. dMCL1-2 degrades MCL1, cleaves Caspase-3, and induces Apoptosis. dMCL1-2 can be used in research related to multiple myeloma. | ||||||||||||||||||||
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Keywords
