1. PROTAC
    Apoptosis
  2. PROTAC
    Bcl-2 Family
    Apoptosis
  3. dMCL1-2

dMCL1-2 

Cat. No.: HY-128360
Handling Instructions

dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1.

For research use only. We do not sell to patients.

dMCL1-2 Chemical Structure

dMCL1-2 Chemical Structure

CAS No. : 2351218-88-5

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Description

dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1[1].

IC50 & Target

KD: 30 nM (MCL1)[1]

Molecular Weight

1163.30

Formula

C₆₁H₆₆N₁₀O₁₂S

CAS No.

2351218-88-5

SMILES

O=S(N(CC1)CCN1C(C=C2)=CC=C2OCC3=C(C4=C(N(CCN5CCN(C(COC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)CC5)C(C(O)=O)=C9CCCOC%10=C(C=CC=C%11)C%11=CC=C%10)C9=CC=C4)C(C)=NN3C)(N(C)C)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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dMCL1-2
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