2413940-56-2
Chemical Structure
NF-κB/MAPK-IN-1
- CAS No.: 2413940-56-2
- Formula:C27H27NO7
- Molecular Weight:477.51
IUPAC Name: (E)-N-(4-(2-acetyl-5-methoxyphenoxy)phenyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
InChIKey: PUWGXAJLVXPFFP-AWNIVKPZSA-N
SMILES: O=C(NC1=CC=C(OC2=CC(OC)=CC=C2C(C)=O)C=C1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3
Biological Activity: NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].
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NF-κB/MAPK-IN-1 | 98.71% | NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research. | ||||||||||||||||||||
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Keywords
