2413986-35-1
Chemical Structure
RORγt Inverse agonist 10
- CAS No.: 2413986-35-1
- Formula:C25H26F6N6O3
- Molecular Weight:572.50
IUPAC Name: 6-methyl-N-(7-methyl-8-(((2S,4S)-2-methyl-1-(4,4,4-trifluoro-3-(trifluoromethyl)butanoyl)piperidin-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)nicotinamide
InChIKey: FUKNWBDJYWPXRK-YOEHRIQHSA-N
SMILES: C[C@H](N(C(CC(C(F)(F)F)C(F)(F)F)=O)CC1)C[C@H]1OC2=C(C)C(NC(C3=CN=C(C)C=C3)=O)=CN4C2=NC=N4
Biological Activity: RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC50 of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R[1]
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RORγt Inverse agonist 10 | 99.13% | RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC50 of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R | ||||||||||||||||||||
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Keywords
